Unlocking the Opportunities of Cell and Gene Therapies


Cell and gene therapies represent both sides of modern healthcare — the hopeful and the concerning. They advance the science of medicine, treating and curing diseases that we struggled to address in the past.

John Rudoy, PHD, Zachary Kornblum, Ryan Keith, and Rick Kelly

4 min read

Editor's Note: The article was originally published in Brink.

Cell and gene therapies represent both the hopeful and the concerning sides of modern health care. They massively advance the science of medicine, treating and curing diseases that we struggled to address in the past. But they are also massively expensive and risk exacerbating inequities that already exist in the health care system. How do we unlock the opportunities of cell and gene therapies while avoiding the risks? Experts from Marsh McLennan Agency and Guy Carpenter weigh in.

On gene therapy:

Cell and gene therapy is a culmination of 100 years of research. We’ve really gotten a bigger understanding of how our genes translate into proteins. And how proteins give rise to specific biological actions. This opens the door to manipulating those biological actions to cure or alter diseases where genetics is the main driver.

On the possibility of gene therapy curing diabetes:

We know that diabetes is a genetic deficit in the pancreas that leads to a lack of insulin production. We know that it’s not necessarily a situation that is life or death because it can be treated with insulin, however there is the opportunity to deliver the gene that produces insulin to a deceased pancreas to then reverse that condition. That is going to be an example where the gene therapy could be something that replaces the current treatment such as insulin.

On who should be paying attention to cell and gene therapy:

These do amazing things for people, but the challenge is around the cost. The drugs can have a price tag of several hundred thousand, plus what’s in the pipeline could be $2-$3 million per dose. So who needs to be paying attention is any entity that is taking the risk of medical and pharmacy claims of a population. Naturally, many people would think of insurance companies, but actually, there are many people who self-fund their medical and pharmacy care — meaning they retain the risk. It puts employers in a position of making very deliberate decisions around covering drugs that are doing incredible things and making sure they’re protecting their business from the financial risk of that coverage.

On how these therapies could affect the health care insurance industry:

We’re starting to see a shift or contemplation in stop-loss contracts or risk-protection contracts looking to exclude protection against these types of drugs. The insurance market is trying to respond with some alternative products that would help offset or protect the risk of these drugs. But I think it’s a real question of: Will the exclusions or the changes in the historical stop-loss market around these drugs be happening more rapidly or broadly than the pace of these alternative products to develop? … The individual exchange market is also probably going to drive some of how these drugs are covered. If the individual exchange market has these drugs covered, it actually makes it easier for the employers to not cover them.

  • John Rudoy, PHD,
  • Zachary Kornblum,
  • Ryan Keith, and
  • Rick Kelly